Bacterial-like PPP protein phosphatases
نویسندگان
چکیده
منابع مشابه
Arabidopsis PPP family of serine/threonine phosphatases.
Serine/threonine-specific phosphoprotein phosphatases (PPPs) are ubiquitous enzymes in all eukaryotes, but their regulatory functions are largely unknown in higher plants. The Arabidopsis genome encodes 26 PPP catalytic subunits related to type 1, type 2A and so-called novel phosphatases, including four plant-specific enzymes carrying large N-terminal kelch-domains, but no apparent homologue of...
متن کاملTwo ancient bacterial-like PPP family phosphatases from Arabidopsis are highly conserved plant proteins that possess unique properties.
Protein phosphorylation, catalyzed by the opposing actions of protein kinases and phosphatases, is a cornerstone of cellular signaling and regulation. Since their discovery, protein phosphatases have emerged as highly regulated enzymes with specificity that rivals their counteracting kinase partners. However, despite years of focused characterization in mammalian and yeast systems, many protein...
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Reversible phosphorylation of cytoskeletal and cytoskeleton-associated proteins is a significant element of endothelial barrier function regulation. Therefore, understanding the mechanisms of phosphorylation/dephosphorylation of endothelial cell cytoskeletal proteins is vital to the treatment of severe lung disorders such as high permeability pulmonary edema. In vivo, there is a controlled bala...
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Preamble Phosphatases constitute a wide class of enzymes which remove a phosphate group from the target substrate by hydrolysing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group. This action is directly opposite to that of phosphorylases and kinases. While kinases phosphorylate cellular substrates by using energetic molecules like ATP, phosphatases, in t...
متن کاملMetaplastic protein phosphatases.
Activity-dependent synaptic plasticity is widely considered to be one of the cellular mechanisms that underlie learning and memory. Long-term potentiation (LTP) is the most intensely studied form of synaptic plasticity, in part because it can be induced at glutamatergic synapses in the mammalian brain, including the hippocampus, a structure known for its involvement in memory function. LTP can ...
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ژورنال
عنوان ژورنال: Plant Signaling & Behavior
سال: 2013
ISSN: 1559-2324
DOI: 10.4161/psb.27365